RiteMED Ceftriaxone Adverse Reactions

The most common adverse effects are hypersensitivity reactions, including skin rashes, urticaria, eosinophilia, fever, reactions resembling serum sickness, and anaphylaxis. Transient increases in liver enzyme values have been reported. Hepatitis and cholestatic jaundice have occurred rarely. Convulsions and other signs of CNS toxicity have been associated with high doses, especially in patients with severe renal impairment. Gastrointestinal adverse effects such as nausea, vomiting, and diarrhea have been reported rarely. Prolonged use may result in overgrowth of non-susceptible organisms and pseudomembranous colitis may develop. There may be pain at the injection site following intramuscular use, and thrombophlebitis has occurred following intravenous infusion. Changes in bowel flora may be more marked because of greater biliary excretion of ceftriaxone; diarrhea may occur more often, especially in children. Biliary sludge or pseudolithiasis due to a precipitate of calcium ceftriaxone has been seen occasionally. Ceftriaxone is highly protein bound and is able to displace bilirubin from albumin binding sites causing hyperbilirubinemia. Neutropenia and rare cases of fatal hemolysis has been reported.